Sex hormone-binding globulin (SHBG) is a protein made by the liver. This hormone controls the amount of testosterone that the body uses. Usually, the use of anabolic steroids can affect SHBG, causing it to decrease, so users are wondering if SARMs also lower these levels. 

The production of SHBG is influenced by genetics, hormonal or metabolic factors. High levels can be due to some medications or hepatitis, and low levels are commonly related to obesity or diabetes.

Or it could be SARMs use. 

Ostarine, which is a common type of SARM, shows to suppress SHBG 31% more than another SARM, Test E. So, this shows that androgen receptor agonists such as SARMs will lower the levels of SHBG. 

Low levels of SHBG mean more available testosterone to be in the system, causing high testosterone symptoms such as:

  • More acne and oily skin
  • Aggressive and irritable behavior
  • Excessive body hair
  • Sleep apnea

Affected patients could also trigger inflammation and follicle death, which leads to permanent hair loss. 

A study showed that the human chorionic gonadotropin (HCG) maintained SHBG at normal levels when taking TRT. This means that SARMs users could also use HCG supplements to maintain SHBG while on their cycle. In this way, it would reduce side effects such as hair loss and other high testosterone symptoms.

Human Chorionic Gonadotropin (HCG) as PCT

PCT is post-cycle therapy, which is a protocol followed after a cycle of androgens such as SARMs. 

After a SARMs cycle, the natural production of testosterone is often suppressed as the body’s way of maintaining proper T levels. In order to maintain your gains and a healthy testosterone level, you must follow a good PCT.

HCG has been looked into as a PCT for many bodybuilders.

HCG is a natural hormone found in women, which plays an important role in pregnancy. For men, it’s useful as it functions like the luteinizing hormone (LH), which is vital in testosterone production. This hormone has also been proven to restore testicular size

Although HCG has little to no side effects, it does come with the risk of dependence. It can also hinder your body’s ability to make LH forever. If you are using HCG as a PCT, it has to be strictly controlled through dosing. 

HCG is commonly used with other PCTs. The dosing should be around 500 to 1000iu per day for 2 to 8 weeks.

About the author 

Simon Courtney

Simon has been involved in the healthcare industry for over 20 years. He has served on the board of several healthcare non-profits and has written numerous articles on health and wellness. He is passionate about helping people improve their health and lives. Simon currently resides in New York City with his wife and two children.

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